Endocrine Abstracts

Introduction: Iodine is the key element for the synthesis of thyroid hormones and its intake modulates the physiology and physiopathology of thyroid gland. In Portugal, endemic goiter has disappeared, but some data make us consider that iodine intake, as in other European areas, is far from being sufficient. Taking into account the potential harmful effects of moderate iodine deficiency during pregnancy, when needs are increased, and the absence of recent data on iodine intake...

Background: Treatment resistance in prostate cancer can be the result of multiple different tumour cell adaptations generating castration-resistant prostate cancer (CRPC). Despite advancements in treatment, CRPC remains a highly lethal disease. Some CRPCs become AR independent with loss of AR expression and lineage plasticity, urgently requiring novel therapeutic strategies. BCL2 can be upregulated in some CRPCs and may be a therapeutic target for this disease subset.<p cl...